Investigador Principal: ALICIA G. ARROYO

Gkontra P, Zak MM, Norton K-A, Santos A, Popel AS, Arroyo AG. A 3D Fractal-Based Approach towards Understanding Changes in the Infarcted Heart Microvasculature. Medical Image Computing and Computer-Assisted Intervention-MICCAI. 2015 Vol. 9351 (series Lecture Notes in Computer Science):173-180. Online ISBN: 978-3-319-24574-4.

Oller J, Alfranca A, Méndez-Barbero N, Villahoz S, Lozano-Vidal N, Martín-Alonso M, Arroyo AG, Escolano A, Armesilla AL, Campanero MR, Redondo JM. C/EBPΒ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. Mol Cell Biol. 2015 Oct;35(19):3409-22. PMID: 26217013.

Martín-Alonso M, García-Redondo AB, Guo D, Camafeita E, Martínez F, Alfranca A, Méndez-Barbero N, Pollán Á, Sánchez-Camacho C, Denhardt DT, Seiki M, Vázquez J, Salaices M, Redondo JM, Milewicz D, Arroyo AG. Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice. Circ Res. 2015 Jul 3;117(2):e13-26. PMID: 25963716.

Arroyo AG, Andrés V. ADAMTS7 in cardiovascular disease: from bedside to bench and back again? Circulation. 2015 Mar 31;131(13):1156-9. PMID: 25712207.

Udi Y, Grossman M, Solomonov I, Dym O, Rozenberg H, Moreno V, Cuniasse P, Dive V, Arroyo AG, Sagi I. Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure. 2015 Jan 6;23(1):104-15. PMID: 25482542.

Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG. An EMMPRIN-y-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. J Cell Sci. 2014 Sep 1;127(Pt 17):3768-81. PMID: 24994937.

Koziol A, Martín-Alonso M, Clemente C, Gonzalo P, Arroyo AG. Site-specific cellular functions of MT1- MMP. Eur J Cell Biol 2012. Review Nov-Dec;91(11-12):889-95. PMID: 22939226.

Koziol A, Gonzalo P, Mota A, Pollán A, Lorenzo C, Colomé N, Montaner D, Dopazo J, Arribas J, Canals F, Arroyo AG. The protease MT1-MMP drives a combinatorial proteolytic program in activated endothelial cells. FASEB J 2012. Nov;26(11):4481-94. PMID: 22859368

Gonzalo P, Moreno V, Gálvez BG, Arroyo AG. MT1-MMP and integrins: Hand-to-hand in cell communication. Biofactors. 2010 Jul-Aug;36(4):248-54. Review. PubMed PMID: 20818710.

Gonzalo P, Arroyo AG. MT1-MMP: A novel component of the macrophage cell fusion machinery. Commun Integr Biol. 2010 May;3(3):256-9. PubMed PMID: 20714408; PubMed Central PMCID: PMC2918771.

Núñez V, Alameda D, Rico D, Mota R, Gonzalo P, Cedenilla M, Fischer T, Boscá L, Glass CK, Arroyo AG, Ricote M. Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10626-31. Epub 2010 May 24. PubMed PMID: 20498053; PubMed Central PMCID: PMC2890831.

Arroyo AG, Iruela-Arispe ML. Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res. 2010 May 1;86(2):226-35. Epub 2010 Feb 12. Review. PubMed PMID: 20154066; PubMed Central PMCID: PMC2856193.

Gonzalo P, Guadamillas MC, Hernández-Riquer MV, Pollán A, Grande-García A, Bartolomé RA, Vasanji A, Ambrogio C, Chiarle R, Teixidó J, Risteli J, Apte SS, del Pozo MA, Arroyo AG. MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Dev Cell. 2010 Jan 19;18(1):77-89. PubMed PMID: 20152179; PubMed Central PMCID: PMC2822729.

Yañez-Mó M, Barreiro O, Gonzalo P, Batista A, Megías D, Genís L, Sachs N, Sala-Valdés M, Alonso MA, Montoya MC, Sonnenberg A, Arroyo AG, Sánchez-Madrid F. MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells. Blood. 2008 Oct 15;112(8):3217-26. Epub 2008 Jul 28. PubMed PMID: 18663148.

Alfranca A, López-Oliva JM, Genís L, López-Maderuelo D, Mirones I, Salvado D, Quesada AJ, Arroyo AG, Redondo JM. PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway. Blood. 2008 Aug 15;112(4):1120-8. Epub 2008 Jun 9. PubMed PMID: 18541723.

Genís L, Gonzalo P, Tutor AS, Gálvez BG, Martínez-Ruiz A, Zaragoza C, Lamas S, Tryggvason K, Apte SS, Arroyo AG. Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells. Blood. 2007 Oct 15;110(8):2916-23. Epub 2007 Jul 2. PubMed PMID: 17606763; PubMed Central PMCID: PMC2018672.

Arroyo AG, Genís L, Gonzalo P, Matías-Román S, Pollán A, Gálvez BG. Matrix metalloproteinases: new routes to the use of MT1-MMP as a therapeutic target in angiogenesis-related disease. Curr Pharm Des. 2007;13(17):1787-802. Review. PubMed PMID: 17584108.

Bravo-Cordero JJ, Marrero-Diaz R, Megías D, Genís L, García-Grande A, García MA, Arroyo AG, Montoya MC. MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J. 2007 Mar 21;26(6):1499-510. Epub 2007 Mar 1. PubMed PMID: 17332756; PubMed Central PMCID: PMC1829373.

Genís L, Gálvez BG, Gonzalo P, Arroyo AG. MT1-MMP: universal or particular player in angiogenesis? Cancer Metastasis Rev. 2006 Mar;25(1):77-86. Review. PubMed PMID: 16680574.

Matías-Román S, Gálvez BG, Genís L, Yáñez-Mó M, de la Rosa G, Sánchez-Mateos P, Sánchez-Madrid F, Arroyo AG. Membrane type 1-matrix metalloproteinase is involved in migration of human monocytes and is regulated through their interaction with fibronectin or endothelium. Blood. 2005 May 15;105(10):3956-64. Epub 2005 Jan 21. Erratum in: Blood. 2006 Mar 15;107(6):2586. PubMed PMID: 15665118.

Gálvez BG, Matías-Román S, Yáñez-Mó M, Vicente-Manzanares M, Sánchez-Madrid F, Arroyo AG. Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells. Mol Biol Cell. 2004 Feb;15(2):678-87. Epub 2003 Dec 2. PubMed PMID: 14657245; PubMed Central PMCID: PMC329288.

Gálvez BG, Matías-Román S, Yáñez-Mó M, Sánchez-Madrid F, Arroyo AG. ECM regulates MT1-MMP localization with beta1 or alphavbeta3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells. J Cell Biol. 2002 Nov 11;159(3):509-21. Epub 2002 Nov 11. PubMed PMID: 12427871; PubMed Central PMCID: PMC2173082.

Gálvez BG, Matías-Román S, Albar JP, Sánchez-Madrid F, Arroyo AG. Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling. J Biol Chem. 2001 Oct 5;276(40):37491-500. Epub 2001 Jul 11. PubMed PMID: 11448964.