Investigador Principal:

LAURA SANZ ALCOBER (2014-actualidad)

LUIS ÁLVAREZ-VALLINA (2012-2013)

Navarro R, Delgado-Wicke P, Nuñez-Prado N, Compte M, Blanco-Toribio A, Nuñez G, Álvarez-Vallina L, Sanz L. "2016. Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation. J Cell Mol Med (in press)".

Blanco-Toribio A, Álvarez-Cienfuegos A, Sainz-Pastor N, Merino N, Compte M, Sanz L, Blanco FJ, Álvarez-Vallina L. "2015. Bacterial secretion of soluble and functional trivalent scFv-based N-terminal trimerbodies. AMB Express. 2015 Dec;5(1):137. doi: 10.1186/s13568-015-0137-0. PMID: 26239030"
Más información en: http://link.springer.com.

Compte M, Sanz L, Álvarez-Vallina L. "2015. In vivo secretion of anti-CD3 × anti-tumor bispecific antibodies by gene-modified cells: over a decade of T-cell engagement. Mol Ther. 2015 Apr;23(4):612-3. doi: 10.1038/mt.2015.36. PMID: 25849422"
Más información en: http://www.nature.com.

Sánchez-Martín D, Sørensen MD, Lykkemark S, Sanz L, Kristensen P, Ruoslahti E, Álvarez-Vallina L. "2015. Selection strategies for anticancer antibody discovery: searching off the beaten path. Trends Biotechnol. 2015 May;33(5):292-301. doi: 10.1016/j.tibtech.2015.02.008. PMID: 25819764"
Más información en: http://www.sciencedirect.com.

Gómez-Maldonado L, Tiana M, Roche O, Prado-Cabrero A, Jensen L, Fernandez-Barral A, Guijarro-Muñoz I, Favaro E, Moreno-Bueno G, Sanz L, Aragones J, Harris A, Volpert O, Jimenez B, del Peso L. "2015. EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination. Oncogene. 2015 May 14;34(20):2609-20. doi: 10.1038/onc.2014.200. PMID: 25023702"
Más información en: http://www.nature.com.

Nuñez-Prado N, Compte M, Harwood S, Álvarez-Méndez A, Lykkemark S, Sanz L, Álvarez-Vallina L. "2015. The coming of age of engineered multivalent antibodies. Drug Discov Today. 2015 May;20(5):588-94. doi: 10.1016/j.drudis.2015.02.013. PMID: 25757598"
Más información en: http://www.sciencedirect.com.

Saenz del Burgo L, Compte M, Aceves M, Hernández RM, Sanz L, Álvarez-Vallina L, Pedraz JL. "2015. Microencapsulation of therapeutic bispecific antibodies producing cells: immunotherapeutic organoids for cancer management. J Drug Target. 2015 Feb;23(2):170-9. doi: 10.3109/1061186X.2014.971327. PMID: 25338126"
Más información en: http://www.tandfonline.com.

Blanco-Toribio A, Lacadena J, Nuñez-Prado N, Álvarez-Cienfuegos A, Villate M, Compte M, Sanz L, Blanco FJ, Álvarez-Vallina L. "2014. Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris. Microb Cell Fact. 2014 Aug 12;13:116. doi: 10.1186/s12934-014-0116-1. PMID: 25112455"
Más información en: https://microbialcellfactories.biomedcentral.com.

Compte M, Alvarez-Cienfuegos A, Nuñez-Prado N, Sainz-Pastor N, Blanco-Toribio A, Pescador N, Sanz L, Alvarez-Vallina L. "2014. Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications. Oncoimmunology. 2014 May 23;3:e28810. PMID: 25057445"
Más información en: http://www.ncbi.nlm.nih.gov.

Guijarro-Muñoz I, Compte M, Álvarez-Cienfuegos A, Álvarez-Vallina L, Sanz L. "2014. Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-?B signaling pathway and proinflammatory response in human pericytes. J Biol Chem. 2014 Jan 24;289(4):2457-68. doi: 10.1074/jbc.M113.521161. PMID: 24307174
Más información en: http://www.jbc.org.

Sánchez-Martín D, Sanz L, Ruoslahti E, Alvarez-Vallina L. "In vivo selection of tumor-specific antibodies". Oncotarget. 2013 Sep 20. [Epub ahead of print] PubMed PMID: 24077798.

Fernández-Periáñez R, Molina-Privado I, Rojo F, Guijarro-Muñoz I, Alonso-Camino V, Zazo S, Compte M, Alvarez-Cienfuegos A, Cuesta AM, Sánchez-Martín D, Alvarez-Méndez AM, Sanz L, Alvarez-Vallina L. "Basement membrane-rich organoids with functional human blood vessels are permissive niches for human breast cancer metastasis". PLoS One. 2013;8(8):e72957. doi: 10.1371/journal.pone.0072957. PubMed PMID: 23951338; PubMed Central PMCID:PMC3738545.

Sánchez-Martín D, Martínez-Torrecuadrada J, Teesalu T, Sugahara KN, Alvarez-Cienfuegos A, Ximénez-Embún P, Fernández-Periáñez R, Martín MT, Molina-Privado I, Ruppen-Cañás I, Blanco-Toribio A, Cañamero M, Cuesta AM, Compte M, Kremer L, Bellas C, Alonso-Camino V, Guijarro-Muñoz I, Sanz L, Ruoslahti E, Alvarez-Vallina L. "Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies". Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13791-6. doi: 10.1073/pnas.1300013110. Epub 2013 Aug 5. PubMed PMID: 23918357; PubMed Central PMCID: PMC3752212.

Guijarro-Munoz I, Compte M, Alvarez-Vallina L, Sanz L. "Antibody gene therapy: getting closer to clinical application?" Curr Gene Ther. 2013 Aug;13(4):282-90. PubMed PMID: 23773178.

Alonso-Camino V, Sánchez-Martín D, Compte M, Nuñez-Prado N, Diaz RM, Vile R, Alvarez-Vallina L. "CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors". Mol Ther Nucleic Acids. 2013 May 21;2:e93. doi: 10.1038/mtna.2013.19. PubMed PMID: 23695536.

Guijarro-Muñoz I, Sánchez A, Martínez-Martínez E, García JM, Salas C, Provencio M, Alvarez-Vallina L, Sanz L. "Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab". Med Oncol. 2013 Jun;30(2):572. doi: 10.1007/s12032-013-0572-1. Epub 2013 Apr 12. PubMed PMID: 23579861.

Compte M, Nuñez-Prado N, Sanz L, Alvarez-Vallina L. "Immunotherapeutic organoids: A new approach to cancer treatment". Biomatter. 2013 Jan 1;3(1). doi:pii: e23897. [Epub ahead of print] PubMed PMID: 23507921; PubMed Central PMCID: PMC3732323.

Quetglas JI, John LB, Kershaw MH, Alvarez-Vallina L, Melero I, Darcy PK, Smerdou C. "Virotherapy, gene transfer and immunostimulatory monoclonal antibodies". Oncoimmunology. 2012 Nov 1;1(8):1344-1354. PubMed PMID: 23243597; PubMed Central PMCID: PMC3518506.

Blanco-Toribio A, Sainz-Pastor N, álvarez-Cienfuegos A, Merino N, Cuesta áM, Sánchez-Martín D, Bonet J, Santos-Valle P, Sanz L, Oliva B, Blanco FJ, álvarez-Vallina L. "Generation and characterization of monospecific and bispecific hexavalent trimerbodies". MAbs. 2013 Jan-Feb;5(1):70-9. doi: 10.4161/mabs.22698. Epub 2012 Dec 5. PubMed PMID: 23221741; PubMed Central PMCID: PMC3564888.

Rommelfanger DM, Compte M, Diaz RM, Ilett E, Alvarez-Vallina L, Thompson JM, Kottke TJ, Melcher A, Vile RG. "The efficacy versus toxicity profile of combination virotherapy and TLR immunotherapy highlights the danger of administering TLR agonists to oncolytic virus-treated mice". Mol Ther. 2013 Feb;21(2):348-57. doi: 10.1038/mt.2012.204. Epub 2012 Sep 25. Erratum in: Mol Ther. 2013 Apr;21(4):913. Grau, Marta C [corrected to Compte, Marta]. PubMed PMID: 23011032; PubMed Central PMCID: PMC3594029.

Santos-Valle P, Guijarro-Muñoz I, Cuesta AM, Alonso-Camino V, Villate M, Alvarez-Cienfuegos A, Blanco FJ, Sanz L, Alvarez-Vallina L. "The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype". PLoS One. 2012;7(6):e39097. doi: 10.1371/journal.pone.0039097. Epub 2012 Jun 19. PubMed PMID: 22723936; PubMed Central PMCID: PMC3378518.

Cuesta AM, Sánchez-Martín D, Blanco-Toribio A, Villate M, Enciso-álvarez K, Alvarez-Cienfuegos A, Sainz-Pastor N, Sanz L, Blanco FJ, Alvarez-Vallina L. "Improved stability of multivalent antibodies containing the human collagen XV trimerization domain". MAbs. 2012 Mar 1;4(2). [Epub ahead of print] PubMed PMID: 22453098; PubMed Central PMCID: PMC3361658.

Guijarro-Muñoz I, Cuesta AM, Alvarez-Cienfuegos A, Geng JG, Alvarez-Vallina L, Sanz L. "The axonal repellent Slit2 inhibits pericyte migration: potencial implications in angiogenesis". Exp Cell Res. 2012 Feb 15;318(4):371-8. doi: 10.1016/j.yexcr.2011.12.005. Epub 2011 Dec 14. PubMed PMID: 22198087.

Sanz L, Compte M, Guijarro-Muñoz I, álvarez-Vallina L. "Non-hematopoietic stem cells as factories for in vivo therapeutic protein production". Gene Ther. 2012 Jan;19(1):1-7. doi: 10.1038/gt.2011.68. Epub 2011 May 12. Review. PubMed PMID: 21562594.

Compte M, Nuñez-Prado N, Sanz L, Alvarez-Vallina L. "In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells". Antibodies 2013, 2(3), 415-425; doi:10.3390/antib2030415 - published online 27 June 2013

Compte, M., Blanco, B., Serrano, F., Cuesta, AM, Sanz, L., Bernad, A., Holliger, P. & Álvarez-Vallina, L. Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA x anti-CD3 diabodies from lentivirally transduced human lymphocytes. Cancer Gene Ther (2007) 14:380-388.

Sánchez-Arévalo Lobo VJ, Cuesta AM, Sanz L, Compte M, Prieto J, Blanco FJ, Álvarez-Vallina, L. Enhanced antiangiogenic therapy with single-chain antibody-collagen XVIII NC1/endostatin domain fusion proteins engineered to exploit matrix remodelling events. Int. J. Cancer (2006) 119:455-62.

Sanz L. & Álvarez-Vallina L. Antibody-based anti-angiogenic cancer therapy. Expert Opin Ther. Targets. (2005). 9:1235-45

Urban JH, Schneider RM, Compte M, Finger C, Cichutek K, Álvarez-Vallina L, Buchholz CJ. Selection of functional human antibodies from retroviral display libraries. Nucleic Acids Res. (2005) 24:33-35..

Sanz, L., Blanco, B. & Álvarez-Vallina L. Antibodies and gene therapy: teaching old “magic bullets” new tricks. Trends Immunol. (2004). 25:85-91.

Blanco, B., Holliger, P., Vile, R. & Álvarez-Vallina, L. Induction of human T-lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted by gene-modified bystander cells. J. Immunol. (2003). 171:1070-1077.

Sanz, L. & Álvarez-Vallina, L. The Extracellular Matriz: a new turn-of-the-screww for anti-angiogenic strategies. Trends Mol. Med. (2003) 9:256-262.

Sanz, L., García-Bermejo, L., Blanco, F. J., Kristensen, P., Feijoo, M., Suárez, E., Blanco, B.& Álvarez-Vallina, L. A novel cell binding site in the coiled-coil domain of laminin involved in capillary morphogenesis. EMBO J. (2003) 22:1508-1517.

Sanz, L., Kristensen, P., Blanco, B., Facteau, S., Russell, S. J., Winter, G. & Álvarez-Vallina, L. Single-chain antibody-based gene therapy: Inhibition of tumor growth by in situ production of phage-derived antibodies blocking functionally active sites of cell-associated matrices. Gene Therapy. (2002). 9:1049-1053.

Sanz, L., Pascual, M., Muñoz, A., González, M. A., Hernández Salvador, & Álvarez-Vallina, L. Development of a computer-assisted high-throughput screening platform for anti-angiogenic testing Microvascular Res. (2002). 63:335-339.

Ruchatz, A., Chester, J., Gough, M., Chong, H., Cosset, F-L., Diaz, R, M., Harrington, K., Álvarez-Vallina, L., & Vile, R. Tumour Antigen Specific Induction of Transcriptionally Targeted Retroviral Vectors from Chimeric Immune Receptor- Modified T Cells. Nature Biotech. (2002). 20:256-263.