Ordenar por fecha >>

Publicaciones actuales:

Sanz L, Compte M, Guijarro-Muñoz I, Álvarez-Vallina L.

"2012. 14. Sanz L, Compte M, Guijarro-Muñoz I, Álvarez-Vallina L. Non-hematopoietic stem cells as factories for in vivo therapeutic protein production. Gene Ther. 2012 Jan;19(1):1-7. PMID: 21562594."

Más Información en http://www.nature.com/gt/journal/v19/n1/...

Mª Angeles Abéngozar, Sergio de Frutos, Sergio Ferreiro, Joaquím Soriano, Manuel Perez-Martinez, David Olmeda, Marco Marenchino, Marta Cañamero, Sagrario Ortega, Diego Megias, Antonio Rodriguez and Jorge L. Martínez-Torrecuadrada.

"2012. Blocking ephrin-B2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis and tumor growth. Blood March 23, 2012. PMID: 22446484"

Más Información en http://bloodjournal.hematologylibrary.or...

Bodelón G, Palomino C, Fernández LA.

"2012. Immunoglobulin domains in Escherichia coli and other enterobacteria: from pathogenesis to applications in antibody technologies. FEMS Microbiol Rev. 2012 Jun 22. PMID: 22724448."

Más Información en http://onlinelibrary.wiley.com/doi/10.11...

Cuesta AM, Sánchez-Martín D, Blanco-Toribio A, Villate M, Enciso-Álvarez K, Alvarez-Cienfuegos A, Sainz-Pastor N, Sanz L, Blanco FJ, Alvarez-Vallina L.

"2012. Improved stability of multivalent antibodies containing the human collagen XV trimerization domain. MAbs. 2012 Mar 1;4(2). PMID: 22453098."

Más Información en https://www.landesbioscience.com/journal...

Jurado P, Fernández LA, de Lorenzo V.

"2012. Production and characterization of a recombinant single-chain antibody (scFv) for tracing the σ(54) factor of Pseudomonas putida. J Biotechnol. 2012 Jul 31;160(1-2):33-41. PMID: 22206981"

Más Información en http://www.sciencedirect.com/science/art...

Koziol A, Martín-Alonso M, Clemente C, Gonzalo P, Arroyo AG.

"2012. Site-specific cellular functions of MT1- MMP. Eur J Cell Biol. 2012 Nov-Dec;91(11-12):889-95. PMID: 22939226."

Más Información en http://www.sciencedirect.com/science/art...

Guijarro-Muñoz I, Cuesta AM, Alvarez-Cienfuegos A, Geng JG, Alvarez-Vallina L, Sanz L.

"2012. The axonal repellent Slit2 inhibits pericyte migration: potencial implications in angiogenesis. Exp Cell Res. 2012 Feb 15;318(4):371-8. PMID: 22198087."

Más Información en http://www.sciencedirect.com/science/art...

Koziol A, Gonzalo P, Mota A, Pollán A, Lorenzo C, Colomé N, Montaner D, Dopazo J, Arribas J, Canals F, Arroyo AG.

"2012. The protease MT1-MMP drives a combinatorial proteolytic program in activated endothelial cells. FASEB J. 2012 Nov;26(11):4481-94. PMID: 22859368"

Más Información en http://www.fasebj.org/content/26/11/4481...

Quetglas JI, John LB, Kershaw MH, Alvarez-Vallina L, Melero I, Darcy PK, Smerdou C.

"2012. Virotherapy, gene transfer and immunostimulatory monoclonal antibodies. Oncoimmunology. 2012 Nov 1;1(8):1344-1354. PMID: 23243597."

Más Información en http://www.ncbi.nlm.nih.gov/pmc/articles...

Santos-Valle P, Guijarro-Muñoz I, Cuesta AM, Alonso-Camino V, Villate M, Alvarez-Cienfuegos A, Blanco FJ, Sanz L, Alvarez-Vallina L

"2012.The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype. PLoS One. 2012;7(6). PMID: 22723936"

Más Información en http://www.plosone.org/article/info%3Ado...

Compte M, Nuñez-Prado N, Sanz L, Alvarez-Vallina L.

"2013. Immunotherapeutic organoids: A new approach to cancer treatment. Biomatter. 2013 Jan 1;3(1). PMID: 23507921"

Más Información en https://www.landesbioscience.com/journal...

Guijarro-Munoz I, Compte M, Alvarez-Vallina L, Sanz L.

"2013. Antibody gene therapy: getting closer to clinical application? Curr Gene Ther. 2013 Aug;13(4):282-90. PMID: 23773178."

Más Información en http://www.eurekaselect.com/111780/artic...

Fernández-Periáñez R, Molina-Privado I, Rojo F, Guijarro-Muñoz I, Alonso-Camino V, Zazo S, Compte M, Alvarez-Cienfuegos A, Cuesta AM, Sánchez-Martín D, Alvarez-Méndez AM, Sanz L, Alvarez-Vallina L.

"2013. Basement membrane-rich organoids with functional human blood vessels are permissive niches for human breast cancer metastasis."

Más Información en http://www.plosone.org/article/info%3Ado...

Ramos-Medina R, Montes-Moreno S, Maestre L, Cañamero M, Rodríguez-Pinilla M, Martínez-Torrecuadrada J, Piris MÁ, Majid A, Dyer MJ, Pulford K, Roncador G.

"2013. BCL7A protein expression in normal and malignant lymphoid tissues. Br J Haematol. 2013;160:106-9. PMID:23043359"

Más Información en http://onlinelibrary.wiley.com/doi/10.11...

Alonso-Camino V, Sánchez-Martín D, Compte M, Nuñez-Prado N, Diaz RM, Vile R, Alvarez-Vallina L.

"2013. CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors. Mol Ther Nucleic Acids.PMID: 23695536."

Más Información en http://www.nature.com/mtna/journal/v2/n5...

Guijarro-Muñoz I, Sánchez A, Martínez-Martínez E, García JM, Salas C, Provencio M, Alvarez-Vallina L, Sanz L.

"2013. Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab. Med Oncol. 2013 Jun;30(2):572. PMID: 23579861."

Más Información en http://link.springer.com/article/10.1007...

Blanco-Toribio A, Sainz-Pastor N, Álvarez-Cienfuegos A, Merino N, Cuesta ÁM, Sánchez-Martín D, Bonet J, Santos-Valle P, Sanz L, Oliva B, Blanco FJ, Álvarez-Vallina L.

"2013. Generation and characterization of monospecific and bispecific hexavalent trimerbodies. MAbs. 2013 Jan-Feb;5(1):70-9. PMID: 23221741."

Más Información en https://www.landesbioscience.com/journal...

Salema V., and L.A. Fernández

"2013. High yield purification of nanobodies from the periplasm of E. coli as fusions with the maltose binding protein. Protein Expression and Purification (2013) 91:42-48. PMID:23856605."

Más Información en http://www.sciencedirect.com/science/art...

Garaulet G, Alfranca A, Torrente M, Escolano A, López-Fontal R, Hortelano S, Redondo JM, Rodríguez A.

"2013. IL10 Released by a New Inflammation-regulated Lentiviral System Efficiently Attenuates Zymosan-induced Arthritis. Mol Ther (2013); 21 (1) 119–130. PMID: 22760540."

Más Información en http://www.nature.com/mt/journal/vaop/nc...

Sánchez-Martín D, Sanz L, Ruoslahti E, Alvarez-Vallina L.

"2013. In vivo selection of tumor-specific antibodies.PMID: 24077798."

Más Información en http://www.impactjournals.com/oncotarget...

Van Audenhove I., Van Impe K., Ruano-Gallego D., De Clercq S., De Muynck K., Hubert T., Perdu S., Vanloo B., Verstraete H., Fernández L.A., and J. Gettemans.

"2013. Mapping cytoskeletal protein function in cells by means of nanobodies. Cytoskeleton 2013 (in press). PMID: 23818458."

Más Información en http://onlinelibrary.wiley.com/doi/10.10...

Sanchez-Martin D et al.

"2013. Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13791-6.PMID: 23918357"

Más Información en http://www.pnas.org/content/110/34/13791...

Salema V., Marín E., Martínez-Arteaga R., Ruano-Gallego D., Margolles Y., Teira X., Gutierrez C., Bodelón G., and L.A. Fernández.

"2013. Selection of single domain antibodies from immune libraries displayed on the surface of E. coli cells with two β-domains of opposite topologies. PLoS ONE (2013) 8 (9):e75126 PMID: 24086454"

Más Información en http://www.plosone.org/article/info%3Ado...

Montes-Moreno S, Ramos-Medina R, Martínez-López A, Barrionuevo Cornejo C, Parra Cubillos A, Quintana-Truyenque S, Rodriguez Pinilla SM, Pajares R, Sanchez-Verde L, Martinez-Torrecuadrada J, Roncador G, Piris MA.

"2013. SPIB, a novel immunohistochemical marker for human blastic plasmacytoid dendritic cell neoplasms: characterization of its expression in major hematolymphoid neoplasms. Blood. 2013;121:643-7. PMID:23165482"

Más Información en http://bloodjournal.hematologylibrary.or...

Rommelfanger DM, Compte M, Diaz RM, Ilett E, Alvarez-Vallina L, Thompson JM, Kottke TJ, Melcher A, Vile RG.

"2013. The efficacy versus toxicity profile of combination virotherapy and TLR immunotherapy highlights the danger of administering TLR agonists to oncolytic virus-treated mice. Mol Ther. 2013 Feb;21(2):348-57. PMID: 23011032."

Más Información en http://www.nature.com/mt/journal/v21/n2/...

Fernández-Periáñez R, Molina-Privado I, Rojo F, Guijarro-Muñoz I, Alonso-Camino V, Zazo S, Compte M, Alvarez-Cienfuegos A, Cuesta AM, Sánchez-Martín D, Alvarez-Méndez AM, Sanz L, Alvarez-Vallina L.

"2013.Basement membrane-rich organoids with functional human blood vessels are permissive niches for human breast cancer metastasis.PLoS One. 2013 Aug 8;8(8):e72957. PMID:23951338"

Más Información en http://www.plosone.org/article/info%3Ado...

Compte M, Nuñez-Prado N, Sanz L, Alvarez-Vallina L.

"2013.In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells. Antibodies 2013, 2(3), 415-425."

Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG.

"2014. An EMMPRIN-gamma-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. J Cell Sci. 2014 Sep 1;127(Pt 17):3768-81. doi: 10.1242/jcs.149518"

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Campuzano S., Salema V., Moreno M., Gamella M., Yañez-Sedeño P., Fernández L.A., and J. M. Pingarrón.

"2014. Disposable amperometric magnetoimmunosensors using nanobodies as biorecognition element. Determination of Fibrinogen in plasma. Biosensors and Bioelectronics (2014) 52:255-260. PMID: 24060974"

Más Información en http://www.sciencedirect.com/science/art...

Blanco-Toribio A, Lacadena J, Nuñez-Prado N, Alvarez-Cienfuegos A, Villate M, Compte M, Sanz L, Blanco FJ, Alvarez-Vallina L.

"2014. Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris. Microb Cell Fact. 2014 Aug 12;13:116. doi: 10.1186/s12934-014-0116-1."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Compte M, Álvarez-Cienfuegos A, Nuñez-Prado N, Sainz-Pastor N, Blanco-Toribio A, Pescador N, Sanz L, Álvarez-Vallina L.

"2014. Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications. Oncoimmunology. 2014 May 23;3:e28810. eCollection 2014."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Guijarro-Muñoz I, Compte M, Alvarez-Cienfuegos A, Álvarez-Vallina L, Sanz L*.

"2014. Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes. J Biol Chem. 2014 Jan 24;289(4):2457-68. doi: 10.1074/jbc.M113.521161."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/24307...

Barreira M, Fabbiano S, Couceiro JR, Torreira E, Martínez-Torrecuadrada JL, Montoya G, Llorca O, Bustelo XR

"2014. The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins. Sci Signal. 2014 Apr 15;7(321):ra35. doi: 10.1126/scisignal.2004993."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Lorenzo C, Pérez-Chacón, Garaulet G, Mallorquín Z, Zapata JM, Rodríguez A

"2015. Efficient expression of bioactive murine IL12 as a self-processing P2A polypeptide driven by inflammation-regulated promoters in tumor cell lines.Cancer Gene Ther (2015); 22, 542-551. PMID: 26450626 ."

Más Información en http://www.nature.com/cgt/journal/v22/n1...

García-Escudero V, Rosales M, Muñoz JL, Scola E, Medina J, Khalique H, Garaulet G, Rodriguez A and Lim F.

"2015. Patient-derived olfactory mucosa for study of the non-neuronal contribution to amyotrophic lateral sclerosis pathology. DOI: 10.1111/jcmm.12488"

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Polyxeni Gkontra, Magdalena M. Zak, Kerri-Ann Norton, Andres Santos, Aleksander Popel, and Alicia G. Arroyo

"2015. A 3D Fractal-Based Approach towards Understanding Changes in the Infarcted Heart Microvasculature. "

MICCAI (Lecture Notes in Computer Science ) (Pag 173-180)

Más Información en http://www.springer.com/computer/lncs?SG...

Arroyo AG, Andrés V.

"2015. ADAMTS7 in cardiovascular disease: from bedside to bench and back again? Circulation. 2015 Mar 31;131(13):1156-9. doi: 10.1161/CIRCULATIONAHA.115.015711."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Bodelón G., Marín E., and L.A. Fernández

"2015. Analyzing the role of periplasmic folding factors in the biogenesis of OMPs and members of the type V secretion system. Methods Mol Biol. 2015;1329:77-110. doi: 10.1007/978-1-4939-2871-2_7."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Blanco-Toribio A, Ana Álvarez-Cienfuegos, Noelia Sainz-Pastor, Nekane Merino, Marta Compte, Laura Sanz, Francisco J. Blanco, Luis Álvarez-Vallina.

"2015. Bacterial secretion of soluble and functional trivalent scFv-based N-terminal trimerbodies. AMB Express. 2015 Dec;5(1):137. doi: 10.1186/s13568-015-0137-0."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Oller J, Alfranca A, Méndez-Barbero N, Villahoz S, Lozano-Vidal N, Martín-Alonso M, Arroyo AG, Escolano A, Armesilla AL, Campanero MR, Redondo JM.

"2015. C/EBPbeta and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. Mol Cell Biol. 2015 Oct;35(19):3409-22. doi: 10.1128/MCB.00494-15."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Martín-Moreno AM, Roncador G, Maestre L, Mata E, Jiménez S, Martínez-Torrecuadrada JL, Reyes-García AI, Rubio C, Tomás JF, Estévez M, Pulford K, Piris MA, García JF.

"2015. CSF1R Protein Expression in Reactive Lymphoid Tissues and Lymphoma: Its Relevance in Classical Hodgkin Lymphoma. PLoS One. 2015 Jun 12;10(6):e0125203. doi: 10.1371/journal.pone.0125203."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Martín-Alonso M, García-Redondo AB, Guo D, Camafeita E, Martínez F, Alfranca A, Méndez-Barbero N, Pollán Á, Sánchez-Camacho C, Denhardt DT, Seiki M, Vázquez J, Salaices M, Redondo JM, Milewicz D, Arroyo AG.

"2015. Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice. Circ Res. 2015 Jul 3;117(2):e13-26. doi: 10.1161/CIRCRESAHA.117.305108."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Gómez-Maldonado L, Tiana M, Roche O, Prado-Cabrero A, Jensen L, Fernandez-Barral A, Guijarro-Muñoz I, Favaro E, Moreno-Bueno G, Sanz L, Aragones J, Harris A, Volpert O, Jimenez B, Del Peso L.

"2015. EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination. Oncogene. 2015 May 14;34(20):2609-20. doi: 10.1038/onc.2014.200."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Piñero-Lambea C., Ruano-Gallego D., and L.A. Fernández

"2015. Engineered bacteria as therapeutic agents. PMID: 26070111 DOI: 10.1016/j.copbio.2015.05.004"

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/26070...

Ruano-Gallego D., Álvarez B., and L.A. Fernández

"2015. Engineering the controlled assembly of filamentous injectisomes in E. coli K-12 for protein translocation into mammalian cells. ACS Synth Biol. 2015 Sep 18;4(9):1030-41. doi: 10.1021/acssynbio.5b00080."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Compte M, Laura Sanz, Luis Álvarez-Vallina

"2015. In vivo secretion of anti-CD3 * anti-tumor bispecific antibodies by gene-modified cells: over a decade of T-cell engagement. Mol Ther. 2015 Apr;23(4):612-3. doi: 10.1038/mt.2015.36."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/25849...

Udi Y, Grossman M, Solomonov I, Dym O, Rozenberg H, Moreno V, Cuniasse P, Dive V, Arroyo AG, Sagi I.

"2015. Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure. 2015 Jan 6;23(1):104-15. doi: 10.1016/j.str.2014.10.012. "

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Maraver A, Fernandez-Marcos PJ, Cash TP, Mendez-Pertuz M, Dueñas M, Maietta P, Martinelli P, Muñoz-Martin M, Martínez-Fernández M, Cañamero M, Roncador G, Martinez-Torrecuadrada JL, Grivas D, de la Pompa JL, Valencia A, Paramio JM, Real FX, Serrano M

"2015. NOTCH pathway inactivation promotes bladder cancer progression. J Clin Invest. 2015 Feb;125(2):824-30. doi: 10.1172/JCI78185."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Piñero-Lambea C., Bodelón G., Fernández-Periáñez R., Cuesta A.M., Álvarez-Vallina L., and L.A. Fernández

"2015. Programming controlled adhesion of E. coli to target surfaces, cells and tumors with synthetic adhesins. ACS Synth Biol. 2015 Apr 17;4(4):463-73. doi: 10.1021/sb500252a. "

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Sánchez-Martín D, Morten Dræby Sørensen, Simon Lykkemark, Laura Sanz, Peter Kristensen, Erkki Ruoslahti, Luis Álvarez-Vallina.

"2015. Selection strategies for anti-cancer antibody discovery: searching off the beaten path. Trends Biotechnol. 2015 May;33(5):292-301. doi: 10.1016/j.tibtech.2015.02.008."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Nuñez-Prado N, Marta Compte, Seandean Harwood, Ana Álvarez-Méndez, Laura Sanz*, Luis Álvarez-Vallina*

"2015. The coming of age of engineered multivalent antibodies. Drug Discov Today. 2015 May;20(5):588-94. doi: 10.1016/j.drudis.2015.02.013."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Lovera S, Morando M, Pucheta-Martinez E, Martinez-Torrecuadrada JL, Saladino G, Gervasio FL

"2015. Towards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational Dynamics. PLoS Comput Biol. 2015 Nov 25;11(11):e1004578. doi: 10.1371/journal.pcbi.1004578. "

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Pucheta-Martínez E, Saladino G, Morando MA, Martinez-Torrecuadrada J, Lelli M, Sutto L, D'Amelio N, Gervasio FL

"2016. An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase. Sci Rep. 2016 Apr 11;6:24235. doi: 10.1038/srep24235."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Navarro R, Pablo Delgado-Wicke, Natalia Nuñez-Prado, Marta Compte, Ana Blanco-Toribio, Gabriel Nuñez, Luis Álvarez-Vallina, Laura Sanz

"2016. Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation. J Cell Mol Med. 2016 May;20(5):980-6. doi: 10.1111/jcmm.12804."

Más Información en http://www.ncbi.nlm.nih.gov/pubmed/?term...

Krusche B, Ottone C, Clements MP, Johnstone E, Goetsch K, Huang L, Mota SG, Singh P, Khadayate S, Ashraf A, Davies T, Pollard SM, De Paola V, Roncaroli F, Martinez-Torrecuadrada JL, Bertone P and Parrinello S.

"2016. EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells. "

eLife (in press)

Más Información en in press...