Investigador Principal: ANTONIO RODRÍGUEZ

Lorenzo C, Pérez-Chacón, Garaulet G, Mallorquín Z, Zapata JM, Rodríguez A. Efficient expression of bioactive murine IL12 as a self-processing P2A polypeptide driven by inflammation-regulated promoters in tumor cell lines. Cancer Gene Ther (2015); 22, 542-551. doi:10.1038/cgt.2015.53 [PUBMED]

Garaulet G, Alfranca A, Torrente M, Escolano A, López-Fontal R, Hortelano S, Redondo JM, Rodríguez A. IL10 Released by a New Inflammation-regulated Lentiviral System Efficiently Attenuates Zymosan-induced Arthritis.
Mol Ther. 2012 Jul 3. doi: 10.1038/mt.2012.131. [PUBMED]

Mª Angeles Abéngozar, Sergio de Frutos, Sergio Ferreiro, Joaquím Soriano, Manuel Perez-Martinez, David Olmeda, Marco Marenchino, Marta Cañamero, Sagrario Ortega, Diego Megias, Antonio Rodriguez and Jorge L. Martínez-Torrecuadrada. "Blocking ephrin-B2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis and tumor growth." Blood. 2012 May 10;119(19):4565-76. [PUBMED]

Katia Urso, Arantzazu Alfranca, Sara Martínez-Martínez, Amelia Escolano, Inmaculada Ortega, Antonio Rodríguez, and Juan Miguel Redondo. NFATc3 regulates the transcription of genes involved in T cell activation and angiogenesis. Blood. 2011 Jul 21;118(3):795-803. [PUBMED]

Rodríguez A, Roy J, Martínez-Martinez S, López-Maderuelo MD, Niño-Moreno P, Ortí L, Pantoja-Uceda D, Pineda-Lucena A, Cyert MS, Redondo JM. A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants Mol Cell. 2009 Mar 13;33(5):616-26. [PUBMED]

Martínez-Martínez S, Genescà L, Rodríguez A, Raya A, Salichs E, Were F, López-Maderuelo MD, Redondo JM, de la Luna S. The RCAN carboxyl-end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators Proc Nat Acad Sci 2009 Apr 14;106(15):6117-22. [PUBMED]

Rodríguez A, Martínez-Martínez S, Rodríguez A, López-Maderuelo MD, Ortega-Pérez I, Vázquez J and Redondo JM. “Blockade of NFAT activation by the second calcineurin binding site”. J Biol Chem. (2006) Mar 10;281(10):6227-35. Epub 2006 Jan 6. [PUBMED]

Buch MH, Pickard A, Rodriguez A, Gillies S, Maass AH, Emerson M, Cartwright EJ, Williams JC, Oceandy D, Redondo JM, Neyses L, Armesilla AL. The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit. J Biol Chem. 2005 Aug 19;280(33):29479-87. Epub 2005 Jun 14. [PUBMED]

Rodríguez A, Martínez-Martínez S, López-Maderuelo MD, Ortega-Pérez I and Redondo JM. “The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT” J.Biol.Chem. (2005) 280, 9980-9984. [PUBMED]

Ruiz de Almodóvar, C., López-Rivas, A., Redondo, J.M., and Rodríguez, A. “Promoter of human TRAIL-R3 gene” Vitamins and Hormones, vol. 67 (Academic Press, Elsevier) pp 51-63 (2004). [PUBMED]

Ruiz-Ruiz C, Ruiz de Almodóvar C, Rodríguez A, Ortiz-Ferrón G, Redondo JM, López-Rivas A. The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1. J Biol Chem. 2004 May 7;279(19):19712-20. Epub 2004 Mar 1. [PUBMED]

Ruiz de Almodóvar C, Ruiz-Ruiz C, Rodríguez A, Ortiz-Ferrón G, Redondo JM, López-Rivas A. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site. J Biol Chem. 2004 Feb 6;279(6):4093-101. Epub 2003 Nov 17. [PUBMED]

Flemington E, Rodríguez A. “Use of gene overexpression to assess function in cell cycle control” Methods in Molecular Biology, vol. 241: Cell Cycle Checkpoint Controls Protocols (Humana Press Inc., Totowa, NK) pp 195-206 (2003).[PUBMED]

Iñiguez, M., Rodríguez, A., Volpert, O., Fresno, M., Redondo, J.M. "Blocking cox-2: new ways to create anti-angiogenic drugs" Trends in Molecular Medicinem (2003) 9:73-78.[PUBMED]

Ruiz de Almodóvar C., López-Rivas A., Redondo JM, Rodríguez, A. “Transcription initiation sites and promoter structure of the human TRAIL-R3 gene” FEBS letters (2002) 531:304-308.[PUBMED]

Lorenzo E, Ruiz-Ruiz C, Quesada AJ, Hernández G, Rodríguez A, López-Rivas A, Redondo JM. Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. J Biol Chem. 2002 Mar 29;277(13):10883-92. Epub 2002 Jan 4. [PUBMED]